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Advances in recent years have highlighted a complex network of factors that govern the persistence of the HIV reservoir, including the chromosomal location of proviral integration, epigenetic controls, clonal and homeostatic proliferation of HIV-infected cells, anatomic barriers, and resistance to immune clearance. Clarifying the mediators of HIV persistence is crucial for designing novel HIV remission strategies that can disrupt these pathways. In this session, we will highlight exciting progress in our understanding of HIV reservoir composition and mechanisms behind HIV persistence, including the contribution of novel technologies that allow unprecedented single-cell resolution.

14:15
2 min
Introduction
Sarah PALMER, The Westmead Institute for Medical Research/University of Sydney, Australia
Mary KEARNEY, National Cancer Institute, United States
14:17
15 min
Hitting a moving target: HIV reservoir dynamics and implications for cure
Zabrina BRUMME, Simon Fraser University, Canada
14:32
15 min
Characterizing HIV integration sites of intact proviruses
Mathias LICHTERFELD, Brigham and Women's Hospital, United States
14:47
15 min
Stepping into the future: Single-cell approaches to studying the HIV reservoir
Linos VANDEKERCKHOVE, UZ Gent, Belgium
15:02
13 min
Q&A
Mary KEARNEY, National Cancer Institute, United States
Sarah PALMER, The Westmead Institute for Medical Research/University of Sydney, Australia
Zabrina BRUMME, Simon Fraser University, Canada
Linos VANDEKERCKHOVE, UZ Gent, Belgium
Mathias LICHTERFELD, Brigham and Women's Hospital, United States
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