Session Type
Date Time

The HPTN071 (PopART) trial was the largest of a series of cluster-randomized studies that tested the impact of community-wide combination HIV prevention packages (including universal testing and treatment) on population level HIV incidence and was conducted in 21 urban and peri-urban communities in Zambia and South Africa between 2011-2018. The main trial outcome, presented and published in 2019 demonstrated an overall 20% reduction in HIV incidence amongst the intervention communities compared with those receiving standard of care. Subsequent long-term and secondary outcomes have now been measured, supported through the TREATS, PANGEA and PopART-phylogenetics consortia. These projects explored the impact of the PopART combination prevention package on TB, HIV transmission patterns, and drug resistance. The HPTN071 (PopART) trial findings remain highly relevant to HIV programmes being implemented in a wide range of settings and can inform the design of local and national policies for HIV and TB control. In this satellite session we will present findings from further analyses and new data from these same PopART communities, examining the impact of community-wide delivery of the PopART intervention on HIV incidence and patterns of transmission, HIV drug resistance, and TB. We aim to address the question "What is our understanding of the lessons learned from PopART and related studies for HIV control, TB control and the role and implementation of universal testing and treatment?"

5 min
Helen AYLES, Zambart, Zambia
10 min
1. Summary of PopART design and main findings
Sarah FIDLER, Imperial College London, United Kingdom
10 min
2. What have we learned from subsequent analysis to better understand our main findings and effects on TB
Richard HAYES, London School of Hygiene and Tropical Medicine, United Kingdom
10 min
3. New data and findings including phylogenetic analysis
Christophe FRASER, Big Data Institute, United Kingdom
10 min
4. Where do we go from here - messages for policy/implementation
Helen AYLES, Zambart, Zambia
15 min
Panel discussion
Rachel BAGGALEY, World Health Organization, Switzerland
Helen AYLES, Zambart, Zambia
David SERWADDA, Makerere University, Uganda
Sarah FIDLER, Imperial College London, United Kingdom
Richard HAYES, London School of Hygiene and Tropical Medicine, United Kingdom
Bactrin KILLINGO, International Treatment Preparedness Coalition, Kenya
Siobhan CROWLEY, The Global Fund, Switzerland